CV

Dr. niti kumar

Principal Scientist

niti.kumar[at]cdri.res.in

+91-522-277 2450

https://cdri.irins.org/profile/220134

Education:

2009: Ph. D. (Biotechnology) Jawaharlal Nehru University/CSIR-Institute of Genomics and Integrative Biology

2004: M. Sc. (Biotechnology), Delhi University

Professional Experience:

Sr. Scientist

2009-2013 Max Planck Institute of Biochemistry

Research Focus

Our lab is interested in the quality control processes adopted by a cell during stress and infection. We are using different biological systems to understand critical pathway(s) involved in genome, proteome and organellar maintenance that help in restoration of cellular homeostasis. (a) Understanding the protein folding and degradation machinery of human host and malaria parasite: We are trying to understand how the protein folding and degradation machinery is able to maintain the parasite’s metastable proteome in soluble and functional state. (b) Probing into telomere dynamics in human malaria parasite: How the evolutionary diversity of telomere-telomerase homeostasis gives competitive edge to the parasite for intracellular survival in human host. (c) Understanding the role of proteins involved in fission-fusion machinery in organellar homeostasis in the malaria parasite: The malaria parasite undergoes transition from uninucleated (ring-stage) to multinucleated (schizont stage). How does the parasite divide its organelles (nucleus, mitochondrion, apicoplast, ER, lysosomes and ER) into the daughter cells. (d) Public-Private venture: Development of indigenous fluorescent dyes, novel quencher and optimization of alternate chemistries for preparation of TaqMan-like probes Technology transferred: SARS-CoV2, Arboviruses (DEN, CHK, ZK) for RT-PCR based clinical diagnosis. (Labs of Atul Goel and Ashish Arora and Niti Kumar) View More...

Selected Publications

1) Adenine modification at C7 as a viable strategy to potentiate the antimalarial activity of Quinolones.
Kurian J, Kumari V, Chaluvalappil SV, Anas M, Manhas A, Kalluruttimmal R,Kumar N*,Manheri MK*.ChemMedChem. 2021 Oct 30. doi: 10.1002/cmdc.202100472., , ,

2)Identification of natural products as potential pharmacological chaperones for protein misfolding diseases.
Sharma R, Srivastava T, Pandey AR, Mishra T, Gupta B, Reddy SS, Singh SP, Narender T, Tripathi A, Chandramouli B, Sashidhara KV, Priya S* and Kumar N* ChemMedChem, 2021, 16 (13): 2146-2156., , ,

3)Structural-functional diversity of malaria parasite’s PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding.
Anas M., Shukla A, Tripathi A, Kumari V, Prakash C, Nag P, Kumar SL, Sharma SK, Ramachandran R and Kumar N* Biochemical Journal, 2020, 477 (18): 3625-3643 , , ,

4)Extra-ribosomal functions of Mtb RpsB in imparting stress resilience and drug tolerance to mycobacteria.
Prakash C, Pandey M, Talwar S, Singh Y, Kanojiya S, Pandey AK, Kumar N* Biochimie, 2020, 177: 87-97 , , ,

5)Protein quality control machinery in intracellular protozoan parasites: hopes and challenges for therapeutic targeting.
Anas M, Kumari V, Gupta N, Dube A, Kumar N* Cell Stress Chaperones, 2019, 24 (5): 891-904, , ,

For complete list of publications click here

Awards & Fellowships

• Swarnajayanti fellowship 2020-21

• SERB (DST) Women Excellence Award 2020

• Selected as member of Indian National Young Academy of Science (INYAS) (2020-2024)

• Innovative Young Biotechnologist Award (IYBA-2015) by Department of Biotechnology DBT).

• Ramalingaswami Fellowship (2013-2018) by Department of Biotechnology (DBT).

Research Group

Ms. Niharika Rai

(Project JRF)

Research:

Ms. Safia Baig

(Project Associate-I)

Research:

Ms. Ariba Mahmood

(Project Associate)

Research:

Mr. Pranshu Tyagi

(Project Associate (PAT-I))

Research:

Ms. SEEMA VIDYARTHI

(UGC-SRF)

Research:

Ms. Nirupa Chaurasia

(CSIR-JRF)

Research:

Mr. SIDDHANT

(UGC-SRF)

Research:

Mr. AMANULLAH SAYEED

(UGC-JRF)

Research:

Ms. Nivedita Gupta

(UGC-JRF)

Research:

Mr. AKASH PANDEY

(CSIR-NET JRF)

Research:

CV

Dr. niti kumar

Principal Scientist

Education:

Professional Experience:

Research Focus

Selected Publications

Awards & Fellowships

Research Group

Ms. Niharika Rai

Ms. Safia Baig

Ms. Ariba Mahmood

Mr. Pranshu Tyagi

Ms. SEEMA VIDYARTHI

Ms. Nirupa Chaurasia

Mr. SIDDHANT

Mr. AMANULLAH SAYEED

Ms. Nivedita Gupta

Mr. AKASH PANDEY

Accessibility options by UX4G