Research and Development

Design and Synthesis of Anti-Osteoporotic agents

Osteoporosis is a global problem, especially associated with women. In India the estimated osteoporotic related fracture cases are in range of 50 million per year. Our designed New Chemical Entity “CENTHANK” CDRI-99/373 is a promising alternative option in the prevention and treatment of osteoporosis. CENTHANK is an orally active and has advantage over the existing clinically used drugs like Raloxifene and Bisphoaphonates in terms of its efficacy as well as toxicity. Cost-effective due to “one pot synthesis” protocol.

CENTHANK /CDRI-99/373 is currently in Phase-I Clinical Trial

Design and Synthesis of Anti-cancer agents
Our designed, novel synthetic compound S007-1235 is identified as a robust lead anti-cancer agent for drug development. The design is based on commonality of tyrosine kinase inhibiting scaffolds that are either drugs or are currently in clinical trials using Hinge region modification. S007-1235 displayed robust cytotoxicity in cancer cells and promising in vivo efficacy in xenograft mouse model. Inhibits proliferation and induces apoptosis in chronic myelogenous leukemia patient samples with higher efficacy than marketed drugs Imatinib and Dasatinib. S007-1235 robustly reduced CD133+ colon and ALDH+ breast cancer stem cell population.



Chemical Approach to Stem Cell and Regenerative Medicine
Stem cell research and Regenerative medicine is an a nascent research area with immense therapeutic future. Our focus is on development of Chemical Approach to Stem cell and Regenerative Medicine in collaboration with CSIR-IIIM and CCMB. Interestingly, a series of our designed compounds are exhibiting promising stem cell modulatory activity.

Effect of CDRI molecules in Zebrafish Caudal Fin Regeneration

Green Chemistry

1. Regioselective Intermolecular Sulfur–Oxygen Difunctionalization (Phenoxysulfonylation) of Alkynes: One-Pot Construction of (Z)-β-Phenoxy Vinylsulfones

Mohd Yeshab Ansari, Navaneet Kumar and Atul Kumar

Org. Lett. 2019, 21, 11, 3931-3936, DOI: 10.1021/acs.orglett.9b01041

2. Amino Acid-Catalyzed Direct Synthesis of β-Keto Sulfones via Aerobic Difunctionalization of Terminal Alkynes in an Aqueous Medium

Navaneet Kumar and Atul Kumar ACS Sustainable Chem. Eng. 2019, 7, 9182-9188,DOI: 10.1021/acssuschemeng.8b06566

3. Zinc Oxide-NP Catalysed Direct Indolation of in situ generated Bioactive Tryptanthrin

Byanju Rai, Ratnakar Dutt Shukla and Atul Kumar Green chem., 2018, 20, 822-826.

4. An Efficient Atom and Step Economic (EASE) Synthesis of Smart Drug Modafinil

Atul Kumar, Shivam Maurya, Dhiraj Yadav and Kemant Pratap Green Chem., 2017, 19, 629-633.

5. β-Cyclodextrin catalysed C–C bond formation via C(sp3)–H functionalization of 2-methyl azaarenes with diones in aqueous medium

Atul Kumar and Ratnakar Dutt Shukla Green Chem., 2015, 17, 848-851.

6. Nanoparticle catalyzed reaction (NPCR): ZnO-NP catalyzed Ugi-reaction in aqueous medium

Atul Kumar, Deepti Saxena and Maneesh Kumar Gupta Green Chem., 2013, 15, 2699-2703.

7. Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water

Atul Kumar, M. Kumar and M. K Gupta Green Chemistry, 2012, 14, 2677-2681

8. Cascade [4+1] annulation via more environmentally friendly nitrogen ylides in water: synthesis of bi and tricyclic fused dihydrofurans

Atul Kumar, S. Srivastava and G. Gupta Green Chemistry, 2012, 14, 3269-3272.

9. L-Proline catalysed multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction under solvent-free conditions

Atul Kumar, M. K. Gupta and M. Kumar Green Chemistry, 2012, 14, 290-295.

10. Functional Ionic Liquid Mediated Synthesis (FILMS) of Dihydrothiophenes and Tacrine Derivatives

Atul Kumar,G. Gupta, S. Srivastava Green Chemistry, 2011, 13, 2459-2463

11. A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction

Atul Kumar,S. Sharma Green Chemistry, 2011, 13, 2017-2020.

12. β-Cyclodextrin catalysed synthesis of tryptanthrin in water

Atul Kumar,V. D. Tripathi and P. Kumar Green Chemistry, 2011, 13, 51-54.