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Supported by:Department of Scientific and Industrial Research (DSIR), Government of India, and the Council of Scientific and Industrial Research (CSIR).

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Pharmacokinetics
IND enabling studies; in-vitro and pre-clinical PK in rodent and non-rodent species. compartment/non-compartment PK modeling and simulation. Preclinical bioavailability and bioequivalence testing of clinical samples.

The facility offers

In vitro pharmacokinetics:- Stability studies (SGF, SIF, plasma, microsome, S9), protien binding, CYP profiling, metabolism studies

Clinical and preclinical pharmacokinetics, metabolism and biodistribution in mice, rats, hamsters, rabbits.

Toxicokinetics

Bioanalytical method development and validation as per regulatory guidelines.

Pharmacokinetic Modeling and simulations

Case Study: Serum concentration vs time profile of isoniazid in monkeys:

(Mean serum concentration versus time profiles of isoniazid in monkeys administered a single i.v. injection (top), a single inhalation of MP containing 0.25, 2.5 and 25 mg of each drug, (middle) and at presumed steady state (bottom). Scatter points corresponding to line colour represent group means (n=4) and error bars show standard deviation (SD). Values from individual animals are also plotted as additional scatter points.)

(Simulation of pharmacokinetics/toxicokinetics following daily dosing with CDRI Compound S011-1793, computed from observations at 45 mg/kg)

Testing Equipment