Reproductive Biology & Cancer Biology
Unique protein domains, concentration gradients, and asymmetric protein distributions or polarities are the Principal factors establishing the identity of gametes and the fate of individual cells during early embryonic development. Our lab, basically strives to identify markers associated with the above mentioned regulatory factors. Their identification and characterization will help to gain significant insights into the process of gamete maturation and early embryonic development in mammals. It is also known that if some of these gonad specific markers start expressing in the normal cells, they can become cancerous. Based on this we are attempting to identify novel cancer biomarkers in our lab and this research study has possible implications in early diagnostics of various cancers as well as developing novel cancer therapies
Services Offered from the Lab
➤ Rodent models having dysfunctional gonads were established to facilitate the screening of pro-fertility strategies.
➤ In-vitro & in-vivo screening for anti-spermatogenic compounds to develop male contraceptives.
➤ In-vivo screening for anti-implantation and anti-ovulatory compounds to develop novel female contraceptives.
➤ Service of providing MAOs (Modified Animal Oocytes) & MAEs (Modified Animal Embryos) to practice embryology are available from our lab.
➤ Rodent model has been established for Benign Prostate Hyperplasia (BPH) and Prostate Cancer.
➤ Rodent model established to study the breach of biological blood barriers.
➤ Nine Transgenic rodent models are being maintained in CDRI.
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