Essential Safety Pharmacology Studies at CSIR-CDRI

We are following schedule y, ICH and OECD guidelines while performing safety pharmacology studies.

Following studies are carried out:

1. Rat Respiration Studies: Studies in Whole body Plethysmograph

2. Blood oxygen saturation studies in rat.

3. CNS Studies in Mice: Body temperature, gross behaviour, motor activity, neuromuscular coordination, sensory reflexes.

4. CVS Studies in Rat: Covering BP, Heart Rate, QT interval.

An additional assay of hERG liability can be carried out by using florescence polarization based assay.