All Publications


Singh V, Rana M, Jain M, Singh, N, Naqvi, A, Malasoni R, Dwivedi AK, Dikshit M and Barthwal MK

Curcuma oil attenuates accelerated atherosclerosis and macrophage foam-cell formation by modulating genes involved in plaque stability, lipid homeostasis and inflammation

British Journal of Nutrition 2015, 113(1),100-113


Kavya, Ramkumar , Saluja, Rohit, Singh, Sarika and Dikshit , Madhu

Nitric oxide synthase regulation and diversity: Implications in Parkinson’s disease

Nitric Oxide 2006, 15, 280-294


Singh M, Singh KP Shukla S and Dikshit M

Assessment of in-utero venlafaxine induced, ros-mediated, apoptotic neurodegeneration in fetal neocortex and neurobehavioral sequelae in rat offspring

International Journal of Developmental Neuroscience 2015, 40 ,60-69


Dubey M, Singh AK, Awasthi D, Nagarkoti S, Kumar S, Ali W, Chandra T, Kumar V, Barthwal MK, Jagavelu K, Sanchez-Gomez FJ, Lamas S and Dikshit M

L-plastin s-glutathionylation promotes reduced binding to î²-actin and affects neutrophil functions

Free Radical Biology and Medicine 2015, 86 ,1-15


Jyoti A, Singh AK, Dubey M, Kumar S, Saluja R, Keshari RS, Verma A, Chandra T, Kumar A, Bajpai VK, Barthwal MK and Dikshit M

Interaction of Inducible Nitric Oxide Synthase with Rac2 Regulates Reactive Oxygen and Nitrogen Species Generation in the Human Neutrophil Phagosomes: Implication in Microbial Killing

Antioxidants & Redox Signaling 2014, 20(3),417-431


Prakash P, Singh V, Jain M, Rana M, Khanna V, Barthwal MK and Dikshit M

Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat

European Journal of Pharmacology 2014, 727 ,15-28


Kumar KSA, Misra A, Siddiqi TI, Srivastava S, Jain M, Bhatta RS, Barthwal M, Dikshit M and Dikshit DK

Synthesis and identification of chiral aminomethylpiperidine carboxamides as inhibitor of collagen induced platelet activation

European Journal of Medicinal Chemistry 2014, 81 ,456-472


Keshari, RS; Verma, A; Barthwal, MK; Dikshit, M

Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils

J Cell Biochem 2013, 114 (3) 532-540,


Dighe SU, Kumar AKS, Srivastava S, Shukla P, Singh S, Dikshit M and Batra S

Regioselective metal-free decarboxylative multicomponent coupling of a-amino acids, aldehydes and lsonitriles leading to n-substituted azacyclic-2-carboxamides with antithrombotic activity

Journal of Organic Chemistry 2015, 80(1),99-108


Jyoti, A; Singh, A; Keshari, R; Kumar, S; Saluja, R; Dubey, M; Verma, A; Bajpai, V; Barthwal, MK; Tripathi, AK; Dikshit, M

Nitric Oxide Synthase - Nitric Oxide Involvement in the Human Neutrophil Free Radical Generation: Role of iNOS and Rac2 Interaction

Blood 2013, 120 (21) -,


Tripathi, AK; Jain, M; Singh, AK; Barthwal, MK; Kumar, A; Dikshit, M

Alterations in the Circulating Nitrite Levels and Expression of NOS Isoforms in the Neutrophils of AML Patients

Blood 2013, 120 (21),


Jain, M; Surin, WR; Misra, A; Prakash, P; Singh, V; Khanna, V; Kumar, S; Siddiqui, HH; Raj, K; Barthwal, MK; Dikshit, M

Antithrombotic Activity of a Newly Synthesized Coumarin Derivative 3-(5-Hydroxy-2,2-dimethyl-chroman-6-yl)-N-{2-[3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-propionylamino]-ethyl}-propionamide

Chemical Biology & Drug Design 2013, 81 (4) 499-508,


Keshari RS, Jyoti A, Kumar S, Dubey M, Verma A, Srinag BS, Krishnamurthy H, Barthwal MK and Dikshit M

Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential

Cytometry A 2012, 81(3), 238-247


Jain M, Barthwal MK, Haq W, Katti SB and Dikshit M

Synthesis and pharmacological evaluation of novel arginine analogs as potential inhibitors of acetylcholine-induced relaxation in rat thoracic aortic rings

Chemical Biology & Drug Design 2012, 79 (4), 459-69


Keshari RS, Jyoti A, Dubey M, Kothari N, Kohli M, Bogra J, Barthwal MK and Dikshit M

Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition

PLOS ONE 2012, 7(10), e48111


Khanna V, Jain M, Barthwal MK, Kalita D, Boruah JJ, Das SP, Islam NS, Ramasarma T and Dikshit M

Vasomodulatory Effect of Novel Peroxovanadate Compounds on Rat Aorta: Role of Rho Kinase and Nitric Oxide/Cgmp Pathway

Pharmacological Res 2011, 64(3), 274-282


Prakash P, Khanna V, Singh V, Jyoti A, Jain M, Keshari RS, Barthwal MK and Dikshit M

Atorvastatin Protects against Ischemia-Reperfusion Injury in Fructose-Induced Insulin Resistant Rats

Cardiovascular Drugs and Therapy 2011, 25(4), 285-297


Prakash P, Misra A, Surin WR, Jain M, Bhatta RS, Pal R, Raj K, Barthwal MK and Dikshit M

Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis

Thrombosis Research 2011, 127 (2), 111-118


Kumar S, Barthwal MK and Dikshit M.

Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle

Free Radical Biol Med 2010, 48(6), 851-861


Patel S, Kumar S, Jyoti A, Srinag BS, Keshari RS, Saluja R, Verma A, Mitra K, Barthwal MK, Krishnamurthy H, Bajpai VK and Dikshit M.

Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation

Nitric Oxide 2010, 22( 3), 226-234


Singh S, Kumar S, and Dikshit M.

Involvement of the Mitochondrial Apoptotic Pathway and Nitric Oxide Synthase in Dopaminergic Neuronal Death Induced by 6-Hydroxydopamine and Lipopolysaccharide

Redox Report 2010, 15(3), 115-122


Surin WR, Prakash P, Barthwal MK and Dikshit M

Optimization of ferric chloride induced thrombosis model in rats: Effect of anti-platelet and anti-coagulant drugs

J Pharmacological and Toxicological Methods 2010, 61(3), 287-291


Kumar S, Patel S, Jyoti A, Keshari RS, Verma A, Barthwal MK, Dikshit M

Nitric oxide-mediated augmentation of neutrophil reactive oxygen and nitrogen species formation: Critical use of probes

Cytometry A 2010, 77(11), 1038-48


Kumar S, Jyoti A, Keshari RS, Singh M, Barthwal MK and Dikshit M.

Functional and molecular characterization of NOS isoforms in rat neutrophil precursor cells.

Cytometry A 2010, 77(5), 467-77


Jyoti A, Keshari RS, Kumar S, Patel S, Srinag BS, Verma A, Barthwal MK, Krishnamurthy H, Bajpai VK and Dikshit M

Nitric oxide dependent increase in free radical generation mediates release of extracellular traps from human neutrophils

FASEB J 2009, 23, 89010


Chatterjee Madhumita, Saluja Rohit, Kumar Vipul, Jyoti Anupam, Jain Girish Kumar, Barthwal Manoj Kumar and Dikshit Madhu

Ascorbate sustains neutrophil NOS expression, catalysis, and oxidative burst

Free Radical Biol Med 2008, 45, 1084-1093


Patel S, Kumar S, Saluja R, Barthwal MK, Mitra K, Verma A, Bajpai VK and Dikshit M

Neutrophil extracellular trap formation by nitric oxide donors: Involvement of nitric oxide synthase and myeloperoxidase derived free radicals

FASEB J 2008, 22, 1072-9


Kumar S, Gupta K Barthwal MK and Dikshit M

Nitric oxide synthesis in neutrophil precursor cells and effect of nitric oxide modulators on their maturation

FASEB J 2008, 22, 749-5


Surin WR, Barthwal MK and Dikshit M

Platelet collagen receptors, signalling and antagonism: Emerging approaches for the prevention of intra-vascular thrombosis

Thrombosis Research 2008, 122, 786-803


Patel S, Kumar S, Barthwal MK and Dikshit M

New insight into the NO-mediated signaling to modulate neutrophil free radical generation.

FASEB J 2007, 21, A623-A623


3. A Misra, KSA Kumar, M Jain, K Bajaj, S Shindya, S Srivastava, P Shukla, Manoj K. Barthwal, Dikshit M, Dinesh K. Dikshit

Synthesis and Evaluation of Dual Antiplatelet Activity of Bispidine Derivatives of N-Substituted Pyroglutamic Acids

European Journal of Medicinal Chemistry 2016, 110 (3), 1-12


9. YS Chhonker, CP Pandey, H Chandasana, TS Laxman, YD Prasad, Narain VS, Dikshit M, Bhatta RS

Simultaneous quantitation of acetylsalicylic acid and clopidogrel along with their metabolites in human plasma using liquid chromatography tandem mass spectrometry

Biomedical Chromatography 2016, 30(3), 466-473


15. Singh AK, Awasthi D, Dubey M, Nagarkoti S, Kumar A, Chandra T, Barthwal MK, Tripathi AK, Dikshit M

High oxidative stress adversely affects NFκB mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chronic myeloid leukemia

Nitric Oxide 2016, 10.1016/j.niox.2016.06.002


6. A Singh, V Singh, RL Tiwari, T Chandra, A Kumar, Dikshit M, MK Barthwal

The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes

Cellular & molecular immunology 2015, 10.1038/cmi.2015.62


Rana M, Reddy SS, Maurya P, Singh V, Chaturvedi S, Kaur K, Agarwal H, Ahmad H, Naqvi A, Dwivedi AK, Dikshit M and Barthwal MK

Turmerone enriched standardized curcuma longa extract alleviates lps induced inflammation and cytokine production by regulating tlr4–irak1–ros–mapk–nfκb axis

Journal of Functional Foods 2015, 16 ,152-16


Singh V, Jain M, Misra A, Khanna V, Prakash P, Malasoni R, Dwivedi AK, Dikshit M and Barthwal MK

Curcuma oil ameliorates insulin resistance & associated thrombotic complications in hamster & rat

Indian Journal of Medical Research 2015, 141(6),823-32


5. AK Tripathi, Dikshit M

Nobel Prize for artemisinin research: Indian side of the story

Current Science 2015, 109 (12), 2172-2173


Manhas A, Khanna V, Prakash P, Goyal D, Malasoni R, Naqvi A, Dwivedi AK, Dikshit M and Jagavelu K.

Curcuma oil reduces endothelial cell-mediated inflammation in postmyocardial ischemia/reperfusion in rats.

Journal of Cardiovascular Pharmacology 2014, 64(3),228-236


Garikipati VN, Jadhav S, Pal L, Prakash P, Dikshit M and Nityanand S.

Mesenchymal Stem Cells from Fetal Heart Attenuate Myocardial Injury after Infarction: An In Vivo Serial Pinhole Gated SPECT-CT Study in Rats

Plos One 2014, 9(6),e100982


Tiwari RL, Singh V, Singh A, Rana M, Verma A, Kothari N, Kohli M, Bogra J, Dikshit M and Barthwal MK

PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes.

Journal Of Lipid Research 2014, 55(7),1226-1244


16. Misra A, Srivastava S, Ankireddy SR, Islam NS, Chandra T, Kumar A, Barthwal MK, Dikshit M.

Phospholipase C-γ2 via p38 and ERK1/2 MAP kinase mediates diperoxovanadate-asparagine induced human platelet aggregation and sCD40L release

Redox Rep 2013, 18(5):174-85


Singh V, Jain M, Misra A, Khanna V, Rana M, Prakash P, Malasoni R, Dwivedi AK, Dikshit M, Barthwal MK

Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters

Brit J Nutr 2013, 110 (3) 437-46,


Kothari N, Bogra J, Kohli M, Malik A, Kothari D, Srivastava S, Keshari RS, Singh V Barthwal MK and Dikshit M

Role of active nitrogen molecules in progression of septic shock

Acta Anaesthesiologica Scandinavica 2012, 56(3), 307 -315


Sashidhara KV, Palnati GR, Avula SR, Singh S, Jain M and Dikshit M

Synthesis And evaluation of anti-thrombotic activity of benzocoumarin amide derivatives

Bioorg Med Chem Lett 2012, 22(9), 3115-21


Kothari N, Keshari RS, Bogra J, Kohli M, Abbas H, Malik A, Dikshit M and Barthwal MK

Increased Myeloperoxidase Enzyme Activity in Plasma Is an Indicator of Inflammation and Onset of Sepsis

J Critical Care 2011, 26(4), 435e1-7


Singh V, Jain M, Prakash P, Misra A, Khanna V, Tiwari RL, Keshari RS, Singh S, Dikshit M and Barthwal MK

A time course study on prothrombotic parameters and their modulation by anti-platelet drugs in hyperlipidemic hamsters

J Physiology and Biochemistry 2011, 67(2) 205-216


Saluja R, Jyoti A, Chatterjee M, Habib S, Verma A, Mitra K, Barthwal MK, Bajpai VK and Dikshit M

Molecular and Biochemical Characterization of Nitric Oxide Synthase Isoforms and Their Intracellular Distribution in Human Peripheral Blood Mononuclear Cells

Biochim Biophys Acta: Molecular Cell Research 2011, 1813(10), 1700-1707


Kumar S, Barthwal MK and Dikshit M

Nitrite mediated modulation of HL-60 cell cycle and proliferation: Involvement of Cdk2 activation

J Pharmacology and Experimental Therapeutic 2011, 337(3), 812-821


Bhalla H, Pant KK, Dikshit M, Surin WR, Singh M

Effect of ormeloxifene,a nonsteroidal once-a-week oral contraceptive on systemic hemodynamics in adult female rats

J Pharmacology and Pharmacotherapeutics 2011, 2011(2), 90-94


Sashidhara KV, Kumar A, Kumar M, Singh S, Jain M and Dikshit M

Synthesis of novel 3-carboxamide-benzocoumarin derivatives as orally active antithrombotic agents

Bioorg Med Chem Lett 2011, 21(23) 7034-7040


Mishra JK, Samanta K, Jain M, Dikshit M and Panda G.

Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents

Bioorg Med Chem Lett 2010, 20(1), 244-247


Saluja Rohit, Saini Rashmi, Mitra Kalyan, Bajpai VK and Dikshit Madhu

Ultrastructural immunogold localization of nitric oxide synthase isoforms in rat and human eosinophils

Cell And Tissue Research 2010, 340(2), 381-8


Saluja Rohit, Saini Rashmi, Mitra Kalyan, Bajpai VK and Dikshit Madhu

Erratum to: Ultrastructural immunogold localization of nitric oxide synthase isoforms in rat and human eosinophils

Cell And Tissue Research 2010, 340(3), 613-613


Babu CK, Ansari KM Mehrotra S, Patel S, Dikshit M and Das M

Activation of inflammatory response and apoptosis of polymorphonuclear leukocytes in patients with argemone oil poisoning

Chemico-Biological Interactions 2010, 183(1), 154-164


Kumar Nikhil, Misra Pragya, Dikshit Madhu, Bhattacharya Shailja Misra, Dube Anuradha and Ranade SA

Piper betle (Betel Vine), a maligned plant of Pan-Asian culture with an array of pharmacological activities: A brighter perspective for drug discovery

Curr Sci 2010, 99, 922-932


Chatterjee M, Saluja R, Tewari S, Barthwal MK, Goel SK and Dikshit M

Augmented nitric oxide generation in neutrophils: oxidative and pro-inflammatory implications in hypertension

Free Radic Res 2009, 43(12), 11 95-204


Patel S, Vemula J, Konikkat S, Barthwal MK and Dikshit M

Ion channel modulators mediated alterations in NO-induced free radical generation and neutrophil membrane potential

Free Radic Res 2009, 43(5), 514-21


Kumar S, Barthwal MK and Dikshit M

Biphasic regulation of cell cycle by nitric oxide donors in promyelocytic HL-60 cell line

FASEB J 2009, 23, 89011


Panday SK, Dikshit M, Dikshit DK

Synthesis of N-[3 '-(acetylthio)alkanoyl] and N-[3 '-mercaptoalkanoyl]-4-alpha(s)-(phenylmethyl) pyroglutamic acids and prolines as potent ACE inhibitors

Med Chem Res 2009, 18(7), 566-578


Singh V, Tiwari RL, Dikshit M and Barthwal MK

Models to Study Atherosclerosis: A Mechanistic Insight

Current Vascular Pharmacology 2009, 7, 75-109


Chatterjee M, Saluja R, Kanneganti S, Chinta S and Dikshit Madhu

Biochemical and molecular evaluation of neutrophil NOS in spontaneously hypertensive rats.

Cellular and Molecular Biology 2007, 15, 84-93


Sharma Preeti, Singh Sangeeta, Siddiqui Tanveer I, Singh Vishnu S, Kundu Bijoy, Prathipati Philip, Saxena Anil K, Dikshit Dinesh K, Rastogi Leena, Dixit Chetna, Gupta MB, Patnaik GK and Dikshit Madhu.

α-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents.

Eur J Med Chem 2007, 42, 386-393


Sankaranarayanan A, Narender T, Kumar S and Dikshit M

Allium sativum constituents: Effect on free radical generation from rat neutrophils.

Cellular and Molecular Biology 2007, 53, 63-67


Das A, Dikshit Madhu and Nath C.

Alteration in acetylcholinesterase glycosylation of rat brain in memory disorder.

FASEB J 2007, 21, A788-A788


4. D Awasthi, S Nagarkoti, A Kumar, M Dubey, AK Singh, P Pathak, Tulika Chandra, Manoj K. Barthwal, Dikshit M

Oxidised LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

Free Radical Biology and Medicine 16, 93, 190-203