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Recent Publications


Taneja I, Raju KS, Singh SP and Wahajuddin M

Assessment of pharmacokinetic compatibility of short acting cdri candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine

Scientific Reports 2015, 5 ,17264


Arora S, Taneja I, Challagundla MK, Raju KSR, Singh SP and Wahajuddin M

In vivo prediction of cyp-mediated metabolic interaction potential of formononetin and biochanin a using in vitro human and rat cyp450 inhibition data.

Toxicology Letters 2015, 239(1),1-8


Raju, KSR, Taneja I, Valicherla GR, Challagundla MK, Rashid M, Syed AA, Gayen JR, Singh SP and Wahajuddin M

No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats

Scientific Reports 2015, 5 ,16126


Taneja I, Raju KSR, Mittal M, Dev K, Khan MF, Maurya R and Wahajuddin M

Oral Bioavailability, plasma protein binding and metabolic stability studies of a aldh2 activator, alda-1, using a validated lc-esi-ms/ms method in rat plasma

RSC Advances 2015, 5(67),54395-54402


Raju KSR, Taneja I, Singh SP, Tripathi A, Mishra DP, Hussain KM, Gayen JR, Singh SK and Wahajuddin M

Simultaneous determination of centchroman and tamoxifen along with their metabolites in rat plasma using lc-ms/ms

Bioanalysis 2015, 7(8),967-979


Wahajuddin M, Singh SP, Taneja I, Raju KSR, Gayen JR, Siddiqui HH and Singh SK

Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and cdri 97-78 in rat plasma using the hplc-esi-ms/ms method: application to drug interaction study

Malaria Journal 2015, 14(1),172-


Selected Publications


Taneja I, Raju KS, Singh SP and Wahajuddin M

Assessment of pharmacokinetic compatibility of short acting cdri candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine

Scientific Reports 2015 , 5 ,17264


Arora S, Taneja I, Challagundla MK, Raju KSR, Singh SP and Wahajuddin M

In vivo prediction of cyp-mediated metabolic interaction potential of formononetin and biochanin a using in vitro human and rat cyp450 inhibition data.

Toxicology Letters 2015 , 239(1),1-8


Raju, KSR, Taneja I, Valicherla GR, Challagundla MK, Rashid M, Syed AA, Gayen JR, Singh SP and Wahajuddin M

No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats

Scientific Reports 2015 , 5 ,16126


Raju KSR, Taneja I, Singh SP, Tripathi A, Mishra DP, Hussain KM, Gayen JR, Singh SK and Wahajuddin M

Simultaneous determination of centchroman and tamoxifen along with their metabolites in rat plasma using lc-ms/ms

Bioanalysis 2015 , 7(8),967-979


Wahajuddin, Raju KS, Singh SP and Taneja I

Investigation of Functional Role of P-glycoprotein in Limiting the Oral Bioavailability of Lumefantrine

Antimicrobial Agents And Chemotherapy 2014 , 58(1),489-494


Wahajuddin; Taneja, I; Arora, S; Raju, KSR; Siddiqui, N

Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems

Current Drug Metabolism 2013 ,14 (4) 369-380,


Wahajuddin; Raju, KSR; Taneja, I

Bioanalysis of antimalarials using liquid chromatography

Trac-Trends In Analytical Chemistry 2013 ,42, 186-204


Wahajuddin, Singh SP, Raju KS, Nafis A and Jain GK

Simultaneous determination of nine model compounds in permeability samples using RP-HPLC: Application to prove the cassette administration principle in single pass intestinal perfusion Study in rats

J Pharm Biomed Anal 2012 ,67(68), 71-6


Wahajuddin, Singh SP, Raju KSR, Nafis A, Puri SK and Jain GK

Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats

Malaria Journal 2011 ,10, 293


All Publications


Raju, KSR, Taneja I, Valicherla GR, Challagundla MK, Rashid M, Syed AA, Gayen JR, Singh SP and Wahajuddin M

No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats

Scientific Reports 2015, 5 ,16126


Taneja I, Raju KS, Singh SP and Wahajuddin M

Assessment of pharmacokinetic compatibility of short acting cdri candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine

Scientific Reports 2015, 5 ,17264


Wahajuddin, Raju KS, Singh SP and Taneja I

Investigation of Functional Role of P-glycoprotein in Limiting the Oral Bioavailability of Lumefantrine

Antimicrobial Agents And Chemotherapy 2014, 58(1),489-494


Arora S, Taneja I, Challagundla MK, Raju KSR, Singh SP and Wahajuddin M

In vivo prediction of cyp-mediated metabolic interaction potential of formononetin and biochanin a using in vitro human and rat cyp450 inhibition data.

Toxicology Letters 2015, 239(1),1-8


Wahajuddin M, Singh SP, Taneja I, Raju KSR, Gayen JR, Siddiqui HH and Singh SK

Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and cdri 97-78 in rat plasma using the hplc-esi-ms/ms method: application to drug interaction study

Malaria Journal 2015, 14(1),172-


Raju KSR, Taneja I, Singh SP, Tripathi A, Mishra DP, Hussain KM, Gayen JR, Singh SK and Wahajuddin M

Simultaneous determination of centchroman and tamoxifen along with their metabolites in rat plasma using lc-ms/ms

Bioanalysis 2015, 7(8),967-979


Wahajuddin, Singh SP, Raju KSR, Nafis A, Puri SK and Jain GK

Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats

Malaria Journal 2011, 10, 293


Wahajuddin, Singh SP, Raju KS, Nafis A and Jain GK

Simultaneous determination of nine model compounds in permeability samples using RP-HPLC: Application to prove the cassette administration principle in single pass intestinal perfusion Study in rats

J Pharm Biomed Anal 2012, 67(68), 71-6


Singh S, Chauhan P, Ravi M, Taneja I, Wahajuddin and Yadav PP

A mild cubr–nmo oxidative system for the coupling of anilines leading to aromatic azo compounds

RSC Advances 2015, 5(76),61876-61880


Dwivedi P, Khatik R, Chaturvedi P, Khandelwal K, Taneja I, Raju KS, Dwivedi H, Singh SK, Gupta PK, Shukla P, Tripathi P, Singh S, Tripathi R, Wahajuddin, Paliwal SK, Dwivedi AK and Mishra PR

Arteether nanoemulsion for enhanced efficacy against plasmodium yoelii nigeriensis malaria: an approach by enhanced bioavailability

Colloids and Surfaces B-Biointerfaces 2015, 126 ,467-475


Taneja I, Raju KSR, Challagundla, MK, Raghuvanshi A, Goel A and Wahajuddin M

Lc-esi-ms/ms method for bioanalytical determination of osteogenic phytoalexin, medicarpin, and its application to preliminary pharmacokinetic studies in rats

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2015, 1001 ,9-16


Taneja I, Raju KSR, Mittal M, Dev K, Khan MF, Maurya R and Wahajuddin M

Oral Bioavailability, plasma protein binding and metabolic stability studies of a aldh2 activator, alda-1, using a validated lc-esi-ms/ms method in rat plasma

RSC Advances 2015, 5(67),54395-54402


Raju KSR, Naveen K, Taneja I and Wahajuddin M

Phytochemical analysis of isoflavonoids using liquid chromatography coupled with tandem mass spectrometry

Phytochemistry Reviews 2015, 14(3),469-498


Cai H, Wahajuddin M, Everett R and Thakker DR

Do cation-selective transporters help or hurt the antitumor efficacy of metformin in breast cancer

Cancer Research 2014, 74(19),4639-4639


Wahajuddin, Taneja I, Erukala M, Raju KS and Singh SP

Dried Blood Spots in Bioanalysis of Antimalarials: Relevance and Challenges in Quantitative Assessment of Antimalarial Drugs

Bioanalysis 2014, 5(17),2171-2186


Tripathi A, Singh SP, Raju KSR, Wahajuddin and Gayen JR

Effect of Red Clover on CYP Expression: An Investigation of Herb-Drug Interaction at Molecular Level.

Indian Journal of Pharmaceutical Sciences 2014, 76(3),261-266


Chauhan P, Ravi M, Singh S, Raju KSR, Bajpai V, Kumar B, Wahajuddin and Yadav PP

Palladium and copper-catalyzed ligand-free coupling of phenylhydrazines in water

RSC Advances 2014, 4 ,43336-43340


Dwivedi P, Khatik R, Khandelwal K, Taneja I, Raju KS, Wahajuddin, Paliwal SK, Dwivedi AK and Mishra PR

Pharmacokinetics study of arteether loaded solid lipid nanoparticles: An improved oral bioavailability in rats

International Journal of Pharmaceutics 2014, 466(1-2),321-327


Dwivedi P, Khatik R, Khandelwal K, Srivastava R, Taneja I, Raju KSR, Dwivedi H, Shukla P, Gupta P, Singh S, Tripathi R, Paliwal SK, Wahajuddin, Dwivedi AK and Mishra PR

Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice

RSC Advances 2014, 4 ,64905-64918


Gupta S, Verma DK, Biswas J, Rama Raju KS, Joshi N, Wahajuddin and Singh S

The metabolic enhancer piracetam attenuates mitochondrion-specific endonuclease G translocation and oxidative DNA fragmentation

Free Radical Biology And Medicine 2014, 73 ,278-290


Dwivedi, Pankaj; Khatik, Renuka; Khandelwal, Kiran; Taneja, Isha; Raju, Kanumuri Siva Rama; Wahajuddin; Paliwal, Sarvesh Kumar; Dwivedi, Anil Kumar; Mishra, Prabhat Ranjan

Pharmacokinetics study of arteether loaded solid lipid nanoparticles: An improved oral bioavailability in rats

INTERNATIONAL JOURNAL OF PHARMACEUTICS 2014, 466(1-2), 321 - 327


Gupta, Sonam; Verma, Dinesh Kumar; Biswas, Joyshree; Raju, K. Siva Rama; Joshi, Neeraj; Wahajuddin; Singh, Sarika

The metabolic enhancer piracetam attenuates mitochondrion-specific endonuclease G translocation and oxidative DNA fragmentation

Free Radical Biol Med 2014, 73, 278 - 290


Tripathi, Anubhuti; Singh, S. P.; Raju, K. S. R.; Wahajuddin; Gayen, J. R.

Effect of red clover on cyp expression: An investigation of herb-drug interaction at molecular level

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 2014, 76(3), 261 - 266


Maurya, R; Soni, A; Anand, D; Ravi, M; Raju, KSR; Taneja, I; Naikade, NK; Puri, SK; Wahajuddin; Kanojiya, S; Yadav, PP

Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes

ACS Medicinal Chemistry Letters 2013, 4 (2) 165-169,


Raju KS, Taneja I, Singh SP, Wahajuddin

Utility of noninvasive biomatrices in pharmacokinetic studie

Biomed Chromatogr 2013, PMID: 23939915,


Tadigoppula, N; Korthikunta, V; Gupta, S; Kancharla, P; Khaliq, T; Soni, A; Srivastava, RK; Srivastava, K; Puri, SK; Raju, KSR; Wahajuddin; Sijwali, PS; Kumar, V; Mohammad, IS

Synthesis and Insight into the Structure-Activity Relationships of Chalcones as Antimalarial Agents

J Med Chem 2013, 56 (1) 31-45,


Wahajuddin; Raju, KSR; Taneja, I

Bioanalysis of antimalarials using liquid chromatography

Trac-Trends In Analytical Chemistry 2013, 42, 186-204


Wahajuddin; Taneja, I; Arora, S; Raju, KSR; Siddiqui, N

Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems

Current Drug Metabolism 2013, 14 (4) 369-380,


Srivastava, K; Tyagi, AM; Khan, K; Dixit, M; Lahiri, S; Kumar, A; Changkija, B; Khan, MP; Nagar, GK; Yadav, DK; Maurya, R; Singh, SP; Jain, GK; Wahajuddin; Trivedi, R; Chattopadhyay, N; Singh, D

Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis

Phytomedicine 2013, 20 (6) 470-480,


Wahajuddin, Singh SP and Jain GK

Gender differences in pharmacokinetics of lumefantrine and its metabolite desbutyl-lumefantrine in rats

Biopharm Drug Dispos 2012, 33(4), 229-234


Wahajuddin and Arora S

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Int J Nanomedicine 2012, 7, 3445-3471


Singh SP, Wahajuddin, Raju KSR, Ali MM, Kohli K and Jain GK

Reduced Bioavailability of Tamoxifen and its Metabolite 4-Hydroxytamoxifen After Oral Administration with Biochanin A (an Isoflavone) in Rats

Phytotherap Res 2012, 26(2), 303-307


Singh SP, Wahajuddin, Tewari D, Pradhan T and Jain GK

PAMPA permeability, plasma protein binding, blood partition, pharmacokinetics and metabolism of formononetin, a methoxylated isoflavone.

Food Chem Toxicol 2011, 49(5), 1056-1062


Gautam AK, Bhargavan B, Tyagi AM, Srivastava K, Yadav DK, Kumar M, Singh A, Mishra JS, Singh AB, Sanyal S, Maurya R, Manickavasagam L, Singh SP, Wahajuddin W, Jain GK, Chattopadhyay N and Singh D

Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats.

J Nutritional Biochemistry 2011, 22(4), 318-27


Wahajuddin, Singh SP, Patel K, Pradhan T, Siddiqui HH, and Singh SK

Prediction of Human Absorption of a Trioxane Antimalarial Drug (Cdri 99/411) Using an in-House Validated in Situ Single-Pass Intestinal Perfusion Model

Arzneimittel-Forschung- Drug Research 2011, 61(9), 532-537


Suryawanshi, Wahajuddin, Gupta RC and Singh SK

Preclinical pharmacokinetics, dose proportionality, gender difference and protein binding study of 16-dehydropregnenolone, an antihyperlipidemic agent, in rats

J Pharmacy and Pharmacology 2011, 63 (1), 41-48


Wahajuddin, Singh SP, Sheelendra P, Singh SK and Jain GK

Quantitation of Lumefantrine in Biological Matrices

Current Pharmaceutical Analysis 2011, 7 (1), 42-46


Singh SP, Wahajuddin, Ali MM, Kohli K and Jain GK

Liquid Chromatography-Mass Spectrometry Method for the Quantification of Tamoxifen and Its Metabolite 4-Hydroxytamoxifen in Rat Plasma: Application to Interaction Study with Biochanin a (an Isoflavone)

J Chromatography B 2011, 879(27), 2845-2851


Singh S, Goswami P, Swarnkar S, Singh SP, Wahajuddin, Nath C and Sharma S

A study to evaluate the effect of nootropic drug-Piracetam on DNA damage in leukocytes and macrophages.

Mutation Research-Genetic Toxicology and Environmental Mutagenesis 2011, 726(1) 66-74


Singh SP, Wahajuddin, Tewari D, Patel K and Jain GK

Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method

Fitoterapia 2011, 82(8), 1206-14


Singh SP,Wahajuddin and Jain GK

Intravenous pharmacokinetics and oral bioavailability of biochanin A in female rats

Med Chem Res 2011, 20, 1627–1631


Singh SP, Wahajuddin, Ali MM and Jain, GK

High-throughput quantification of isoflavones, biochanin A and genistein, and their conjugates in female rat plasma using LC-ESI-MS/MS: Application in pharmacokinetic study

J Separation Science 2010, -33, 3326–3334


Singh SP, Wahajuddin, Yadav DK, Rawat Preeti, Maurya Rakesh and Jain GK

Quantitative determination of formononetin and its metabolite in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry

J Chromatogr B Analyt Technol Biomed Life Sci 2010, 878( 3-4), 391-397


Sharan K, Swarnkar G, Siddiqui JA, Kumar A, Rawat P, Kumar M, Nagar GK, Manickavasagam L, Singh SP, Mishra G, Wahajuddin, Jain GK, Maurya R and Chattopadhyay N

A novel flavonoid, 6-C-beta-d-glucopyranosyl-(2S,3S)-(+)-3',4',5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana Planchon mitigates ovariectomy-induced osteoporosis in rats

Menopause 2010, 17 (3), 577-586


Wahajuddin, Singh SP and Jain GK

Determination of lumefantrine in rat plasma by liquid-liquid extraction using LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study

J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877(11-12), 1133-9


Singh Sheelendra P, Singh Ravishankar P, Wahajuddin and Jain Girish Kumar

Development and validation of a rapid, sensitive liquid chromatography tandem mass spectrometry method using electrospray ionization for quantitation of Centchroman in rat plasma and its application to preclinical pharmacokinetic study

J Chromatography 2008, B 876, 1-7