Vision and Goal
➤ Rational design, synthesis and biological screening of synthetic compounds and natural products for discovery of new drug
➤ Repositioning of bioactives
➤ Maintenance of the Repository of Synthetic and pure Natural Compounds for identification of ligands for new biochemical targets
➤ Recruiting compounds from other institutions for assessment of bioactivity
Core Competencies and Activities
➤ Rational design and synthesis of novel organic compounds
➤ Bio-evaluation of synthetic molecules and natural compounds for different disease areas via in vitro and in vivo models
➤ Computational approaches toward identification of new ligands for different targets
➤ Archiving of chemical libraries in the Repository of organic compounds
➤ Maintenance of records of the attributes of each compound with respect to analytical, spectroscopic and biological screening data via the Online Compound Submission and Bioassay Reporting System (CBRS)
➤ Maintenance of SOPs for all bioassays listed and formulation of decision trees for taking the bio-actives to translational mode
➤ Recruiting of organic molecules from other academic institutions for maintenance and bio-evaluation as prelude to discover new bioactives
➤ Analysis of PK parameters of Hits
Drug Discovery At CDRI
➤ Natural Source- Ayurveda/ Ayush
➤ Traditional Source-Inspired Lead
➤ Synthetic Chemistry- Target-Based
➤ Repurposing/Repositioning Of Drug (For Affordable Healthcare)
Repository of Organic Compounds at CSIR-CDRI
Repository of Organic Compounds at CSIR-CDRI
Compound Work flow- Monitoring by the NDDG
Preliminary Bioassay System currently operational at CSIR-CDRI
Cancer
➤ Phenotypic Breast Cancer, Colorectal Cancer
➤ Target-based assays (HDAC, mTOR, proteasome, AKT-kinase)
Parasitic diseases
➤ Antimalarial (P. falciparum, 3D7 and K1 strains)
➤ Antimalarial (Liver stage, secondary screening only)
➤ Antileishmanial (L. donovani, promastigote/ amastigote)
➤ Antifilarial (Micro and Macrofilaricidal)
CNS/CVS disorders
➤ GPCRs Profiling (5HT2C, H3R, KOR, D5, 5-HT6)
➤ Anti-Angiogenesis
➤Anti-Dyslipidemic (Adipogenesis)
➤ Anti-Dyslipidemic (PCSK9)
➤ Anti-Pulmonary hypertension (Tyrosine kinase inhibition)
➤ Anti-Hypertension (ACE Inhibition)
➤ Anti-Parkinson’s Activity (Synuclein aggregation))
➤ Anti-Parkinson’s Activity (C. elegans Synuclein aggregation)
➤ Anti-Inflammatory
Tuberculosis and Microbial Infection
➤Antibacterial (general)
➤ Antibacterial (resistant)
➤Antifungal
➤ Antitubercular
Reproductive Health Research, Diabetes and energy metabolism
➤ Diabetes (Small molecule GLP-1R agonist)
➤ Diabetes Skeletal muscle glucose uptake
➤ Osteoporosis
➤ Spermicidal