Dipak Datta, Ph.D.
Principal Scientist, Cancer Biology
Understand the promiscuity and redundancy of Chemokine Receptor
Signaling in cancer
Central goal of our lab is to understand the genetic and epigenetic regulations of solid tumor heterogeneity, cellular plasticity and drug resistance.
Verma A et al., Nat Commun. 2022 Nov 29;13(1):7344. (PMID: 36446780)
Singh et al., Int. J. Cancer, 1; 136(9):1991-2000. (2015)
Singh A, Verma A et al., Epigenetics, in press (2021)
It has long been known that solid tumors are heterogeneous in nature and each tumor cell has different tumorigenic and metastatic potential. Single tumor cell within a heterogeneous tumor is dynamic in nature and a continuously evolving entity. Genetic, epigenetic and micro-environmental cues are known to be the key players in this process and we try to understand the bases of these regulations by analyzing patient sample data as well as utilizing our in-vitro and in-vivo tumor models. Here is our recent publication highlighting the fact that how an epigenetic modulator changes the metastatic landscape of Triple Negative Breast Cancer (TNBC).