Screen Reader Access







image01

J Venkatesh Pratap, Ph.D.

Chief Scientist, Molecular and Structural Biology




The group works on the structural and functional characterization of proteins from pathogens, focusing on Neglected Tropical Diseases (NTDs) using structural biology complemented with biochemical and computational approaches. NTDs comprise various parasitic and bacterial infections that prevail in the tropical and sub-tropical regions of the world affecting ~ a billion people. Specific interests of the group includes the L. donovani polyamine biosynthesis & purine salvage pathways, V. cholerae transcription machinery & mechanistic aspects of coiled coils & other helical assembly. The group also collaborates with other groups in characterizing of proteins of their interests.

View More..

Education

B.Sc. (Physics) 1989 – 1992 Madurai Kamaraj University

M.Sc (Physics) 1992 – 1994 Madurai Kamaraj University

Ph.D (Crystallography & Biophysics) 2001 Indian Institute of Science, Bengaluru


Postdoc

Nov2001 – Sep 2006 Post Doctoral Research Associate Department of Biochemistry University of Cambridge, England




Positions

Nov 2006 – Nov 2010 Senior Scientist MSB Division, CSIR-CDRI

Nov 2010 – Nov 2015 Principal Scientist MSB Division, CSIR-CDRI

Nov 2015 – present Sr. Pr. Scientist MSB Division, CSIR-CDRI



Contact Details

Email id: jvpratap[AT]cdri.res.in


Tel: 0522-2772450 EPABX-4439


Selected Publications

Karade, S.S., Ahmad, A, Srivastava, V.K., Nayak, A.R. and J. Venkatesh Pratap* (2020) . Molecular and Structural analysis of a mechanical transition of helices in the L. donovani coronin coiled-coil domain Intl. J. Biol. Macromol. 143, 785-796.


Karade Sharanbasappa Shrimant?1, Shilpika Pandey?2, Ahmadullah Ansari1, Sarita Tripathi1, Ashish Arora1, Sidharth Chopra2, J Venkatesh Pratap* 1 and Arunava Dasgupta (2018). Crystal structure of Rv3272 from Mycobacterium tuberculosis, a Class III CoA transferase and its biomolecular interactions with Acyl-CoA ligands. Biochim. Biophys. Acta 1867 317-330.


Mishra, A.K., Singh, N., Agnihotri, P., Singh, S.P., Kolli, B.K., Chang, K.P., Siddiqi, M.I. & Pratap, J.V. (2017) Structural, Functional characterization and discovery of novel inhibitors of Leishmania amazonensis Nucleoside Diphosphatase Kinase (NDK) J. Comput Aided Mol. Des. 31 (6); 547-562.


Agnihotri, P., Mishra, A.K., Mishra, S., Sirohi, V.K., Sahasrabuddhe, A.A. & Pratap, J.V. (2017). Identification of novel inhibitors of Leishmania donovani ?-glutamylcysteine synthetase using structure based virtual screening, docking, molecular dynamics simulation and in vitro studies J. Chem. Inf Model Apr 24;57(4):815-825


Nayak, A.R., Karade, S.S., Srivastava, V.K., Rana, A.K., Gupta, C.M., Sahasrabuddhe, A.A. And Pratap, J.V. (2016) Structure of Leishmania donovani coronin coiled coil domain reveals an antiparallel 4 helix bundle with inherent asymmetry J. Str. Biol. 195 (1), 129-138.

For Full Publications:
pubmed.ncbi.nlm.nih.gov/?term=pratap%2C%20jv&page=2


Awards & Fellowships


Research Group

View All...